What are antisperm antibodies, how common is it, what are the causes, can it prevent pregnancy and can antisperm antibodies be cured?
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Antibodies are immunoglobulin which are a big, Y-shaped protein. It is used by the human immune system to discover and destroy strange things such as pathogenic bacteria and viruses.
What Are Antisperm Antibodies?
Antisperm Antibodies see sperm as a stranger, thereby tampering, destroying and killing it.
Infertility has been a common challenge in couples, It affects one out of every six couples and in an infertile couples, 10-20% has no specific reason but in 9-36% of these infertile couples, antisperm antibodies have been identified as the cause of infertility.
In 1922, Samuel R. Meaker was the first to diagnose presence of antisperm antibodies in women
How Common Are Antisperm Antibodies?
Antisperm antibodies, even though not common, are seen in both male and female. It is seen in 9–12% of patients who are infertile. For an unexplainable cause, it is also present in fertile male and females, this shows that antisperm antibodies do not directly affect fertility. More research is still needed on this.
Antisperm Antibodies In Males
It is present in 4% infertile males.
When a male testicles which keeps the sperm from the other parts of the body and immune system is damaged, or has a prostate gland infection, or a vasectomy. The sperm moves about without restriction and when it comes in contact with the immune system, it is seen as a stranger and destroyed.
Antibodies Antibodies In Females
Some females do have an allergic reaction to her partner’s semen, This will make her immune system to develop antisperm antibodies which attack the semen. This is a non common cause of infertility in female
Can Antisperm Antibodies Cause Infertility
According to this 2015 study, there was a significant negative effect of Antisperm antibodies on sperm concentration, sperm motility.
A study was performed to determine antisperm antibodies in cervicovaginal secretions and serum of infertile women and also measured serum levels of immunoglobulins. The result showed that antisperm antibodies in females do play a significant role on reproduction.
Causes Of Antisperm Antibodies
Let’s examine the causes in male and female
Causes of Antisperm Antibodies In Male
- The break down of blood testis barrier
- Testicular cancer
- Anal sex
Causes of Antisperm Antibodies In Female
- Female whose partner has tend to have too and it is likely this happen only to their partner semen
- cross-reactivity with microbial antigens
- Anal Sex
Symptoms Of Antisperm Antibodies
Can chronic inflammation be a symptom of anti sperm antibodies?
This research evaluates the formation of Antisperm antibodies in chronic inflammatory and infectious diseases of the male reproductive tract but found no relationship between the two.
There is also no link between genital secretion and antisperm antibodies
Diagnosis Of Antisperm Antibodies
The two test presently recommended by WHO to diagnose are
1. Mixed Antiglobulin Reaction (MAR)
2. Immunobead Test (IBT)
Treatment of Antisperm Antibodies
Clinical way to treat are:
- intrauterine insemination
- In vitro fertilization
- intracytoplasmic sperm injection
Analysed above are all you need to know about anti sperm antibodies.